Deep-frying oil intake and risk of intestinal barrier dysfunction: a systematic review and meta-analyses

Deep-frying oil intake is considered to destroy body health. In this review, a meta-analysis was performed to assess the effects of deep-frying oil intake on the risk of intestinal barrier dysfunction. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic literature search was conducted in PubMed, Embase and Cochrane Central updated till April 2022 (CRD42022326306). A total of nine studies were included. The pooled results revealed that deep-frying oil intake significantly exaggerated crypt damage of colon [weighted mean difference (WMD) = 4.55; 95% CI: 2.87, 6.24, P < 0.05], increased proinflammatory cytokine expression in plasma and colon tissue, and enhanced intestinal permeability [lipopolysaccharides content (WMD: 10.11 mu g mL(-1), 95% CI: 7.44, 12.79 mu g mL(-1), P < 0.05)]. Moreover, deep-frying oil intake could change the gut microbiota and decrease the content of microbiota-derived short-chain fatty acids. In conclusion, our findings provide insights into the effect of deep-frying oil intake on the intestinal barrier dysfunction.