Bronchoalveolar Lavage Fluid Eosinophilia Associates with Chronic Lung Allograft Dysfunction Risk: A Multicenter Study.

Jamie L Todd,Jeremy M Weber,Francine L Kelly,Megan L Neely,Hillary Mulder,Courtney W Frankel, Andrew Nagler,Christopher McCrae,Paul Newbold, Jim Kreindler,Scott M Palmer

Chest（2023）

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摘要

BALF eosinophilia was an independent predictor of future CLAD risk across a multicenter lung recipient cohort. Additionally, type 2 inflammatory signals were induced in established CLAD. These data underscore the need for mechanistic and clinical studies to clarify the role of type 2 pathway-specific interventions in CLAD prevention or treatment.

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关键词

Acute rejection,Bronchoalveolar lavage fluid,Chronic lung allograft dysfunction,Eosinophils,Lung transplantation

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