Supplementary Figures 1-13 from Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis

PDF file - 1MB, Supplemental Figures 1-13 - Figure S1. Average levels of focal amplification and deletion along the chromosome arm; Figure S2. Patterns of chromosomal instability differ across adenocarcinomas of the gastrointestinal tract after removing samples without arm-level alterations; Figure S3. Numbers of high-level amplifications and deletions using arm-level based thresholds; Figure S4. Identification of arm-level alterations in esophageal, gastric, and colorectal adenocarcinomas; Figure S5. Comparison of SNP6.0 and 250K adenocarcinoma data to Progenetix database; Figure S6. Significance of focal amplifications in esophageal, gastric, and colorectal adenocarcinomas; Figure S7. Variable levels of focal alterations across gut adenocarcinomas; Figure S8. KRAS alterations differ across gut adenocarcinomas; Figure S9. Quantitative real-time PCR confirms FGFR2 amplification in EA tumors; Figure S10. Focal alterations in gut adenocarcinomas shared with all cancers; Figure S11. Significance of focal deletions in esophageal, gastric, and colorectal adenocarcinomas; Figure S12. Length distribution of SCNAs in gut adenocarcinomas; Figure S13. Observed distribution of copy number event amplitudes in the data set.