Supplementary Figures 1 - 7 from Glioblastoma Stem Cells Are Regulated by Interleukin-8 Signaling in a Tumoral Perivascular Niche

PDF file - 1076K, Immunofluorescence staining of GBM CSCs cultured in the presence of serum and absence of EGF and bFGF (S1); Tumors formed from CSC-seeded PLG scaffold implantation exhibit clinical features of human GBM (S2); Vascular characteristics of tumors formed from PLG scaffold implantation (S3); CSC differentiation is impaired by 3-D hCMEC paracrine signaling cues (S4); Control experiments evaluating IL-8-induced chemotaxis and gene expression in CSCs (S5); Targeted knockdown of CXCR2 in GBM CSCs (S6); Tumor vascularization was not affected by siRNA-knockdown of IL-8 in CSCs (S7).