Supplementary Figures 1-8 from PDGFRα and β Play Critical Roles in Mediating Foxq1-Driven Breast Cancer Stemness and Chemoresistance

Supplementary Figures 1-8. Supplementary Figure 1: EMT promoting transcription factors induce stemness characteristics in mammary epithelial cells. Supplementary Figure 2: The role of Foxq1 in drug resistance, mammosphere formation and tumor initiation. Supplementary Figure 3: Twist1 and Zeb2 regulate PDGFRs. Supplementary Figure 4: Correlation and survival analysis of Foxq1 and Twist1 with PDGFRα and PDGFRβ in tumor samples. Supplementary Figure 5: Effect of PDGFRα and PDGFRβ on cell migration, invasion and stem cell characteristics. Supplementary Figure 6: The effect of imatinib treatment on PDGFRs phosphorylation, mammosphere formation and EMT. Supplementary Figure 7: The Effect of PDGFRs and the treatment of imatinib on chemoresistance. Supplementary Figure 8: Immunohistochemistry (IHC) assays using tumor samples and our working model.