Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming.
Allan C deCamp,Martin M Corcoran,William J Fulp,Jordan R Willis,Christopher A Cottrell,Daniel L V Bader,Oleksandr Kalyuzhniy,David J Leggat,Kristen W Cohen,Ollivier Hyrien,Sergey Menis,Greg Finak,Lamar Ballweber-Fleming,Abhinaya Srikanth,Jason R Plyler,Farhad Rahaman,Angela Lombardo,Vincent Philiponis,Rachael E Whaley,Aaron Seese,Joshua Brand,Alexis M Ruppel,Wesley Hoyland,Celia R Mahoney,Alberto Cagigi,Alison Taylor, David M Brown,David R Ambrozak,Troy Sincomb,Tina-Marie Mullen,Janine Maenza,Orpheus Kolokythas,Nadia Khati,Jeffrey Bethony,Mario Roederer,David Diemert,Richard A Koup,Dagna S Laufer,Juliana M McElrath,Adrian B McDermott,Gunilla B Karlsson Hedestam,William R Schief medRxiv : the preprint server for health sciences(2023)
摘要
Human genetic variation can modulate the strength of vaccine-induced broadly neutralizing antibody precursor B cell responses.
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