ARBM101 (Methanobactin SB2) Drains Excess Liver Copper via Biliary Excretion in Wilson's Disease Rats. Claudia Einer , Ditte Emilie Munk , Eok Park , Banu Akdogan , Judith Nagel , Josef Lichtmannegger , Carola Eberhagen , Tamara Rieder , Mikkel H Vendelbo , Bernhard Michalke , Ralf Wimmer , Andreas Blutke , Annette Feuchtinger , Philip Dershwitz , Ana A DiSpirito , Tawhidul Islam , Rui E Castro , Byong-Keol Min , TaeWon Kim , Seoyoung Choi , Dasol Kim , Chunwon Jung , Hongjae Lee , Dongsik Park , Weonbin Im , So-Young Eun , You-Hee Cho , Jeremy D Semrau , Cecília M P Rodrigues , Simon Hohenester , Thomas Damgaard Sandahl , Alan A DiSpirito , Hans Zischka Gastroenterology（2023）
摘要
ARBM101 safely and efficiently depletes excess liver copper from WD rats, thus allowing for short treatment periods as well as prolonged in-between rest periods.
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关键词
Copper Depletion, Liver, Methanobactin, Mitochondria, Wilson’s Disease
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