An Improved Method for Estimating Nephron Number and the Association of Resulting Nephron Number Estimates with Chronic Kidney Disease Outcomes.

Aleksandar Denic,Aidan F Mullan,Mariam P Alexander,Luke D Wilson,Joshua Augustine,Anthony C Luehrs,Mark D Stegall,Timothy L Kline,Vidit Sharma,R Houston Thompson,Andrew D Rule

Journal of the American Society of Nephrology : JASN（2023）

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摘要

Compared with an older method for estimating nephron number, a new method that addresses several sources of bias results in nephron number estimates that are 27% higher in donors and 1% higher in patients with tumor and shows consistency between two populations. Low nephron number independently predicts CKD in both populations.

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关键词

kidney biopsy, epidemiology and outcomes, nephron, CKD, renal morphology

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