A semi-automated software program to assess the impact of second reads in prostate MRI for equivocal lesions: results from a UK tertiary referral centre

•Semi-automated workflows are useful to contour lesions, calculate prostate volume, and create a structured report for accurate biopsy targeting.•Second reads could be helpful to reduce the number of indeterminate lesions, which harboured clinically significant disease after targeted biopsy only in a minority of cases.•Second reads using customised workflows could help defer biopsies, reducing the number of side effects.