VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats.

Anne-Maj Samuelsson,Theda Ulrike Patricia Bartolomaeus, Harithaa Anandakumar,Irene Thowsen,Elham Nikpey,Jianhua Han,Lajos Marko,Kenneth Finne,Olav Tenstad, Johannes Eckstein,Nikolaus Berndt,Titus Kühne,Sarah Kedziora,Ibrahim Sultan,Trude Skogstrand,Tine V Karlsen,Harri Nurmi,Sofia K Forslund,Entela Bollano,Kari Alitalo,Dominik N Muller,Helge Wiig

Cardiovascular research（2023）

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摘要

This study shows that the VEGF-B TG accelerates metabolic maladaptation which precedes structural cardiomyopathy in experimental hypertension and ultimately leads to systolic HF.

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关键词

Aldosterone,Cardiac hypertrophy,Heart failure,Metabolism,Salt,VEGF-B

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