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RyR2-targeting therapy prevents left ventricular remodeling and ventricular tachycardia in post-infarction heart failure

Shohei Fujii,Shigeki Kobayashi,Yaowei Chang,Junya Nawata,Ryosuke Yoshitomi,Shinji Tanaka,Michiaki Kohno,Yoshihide Nakamura,Hironori Ishiguchi,Takeshi Suetomi,Hitoshi Uchinoumi,Tetsuro Oda,Shinichi Okuda,Takayuki Okamura,Takeshi Yamamoto,Masafumi Yano

Journal of Molecular and Cellular Cardiology（2023）

引用 35|浏览10
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摘要
Pharmacological or genetic stabilization of RyR2 tetrameric structure improves survival after MI by suppressing LV remodeling and proarrhythmia.
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关键词
Calmodulin,Dantrolene,Heart failure,Myocardial infarction,Ryanodine receptor,Ventricular tachycardia
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