SGLT2i alleviates epicardial adipose tissue inflammation by modulating ketone body-glyceraldehyde-3-phosphate dehydrogenase malonylation pathway.

Lina Li,Cuncun Hua,Xiaoyan Liu,Yidan Wang,Lei Zhao,Yeping Zhang,Li Wang,Pixiong Su,Min-Fu Yang,Boqia Xie

Journal of cardiovascular medicine (Hagerstown, Md.)（2023）

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摘要

SGLT2i alleviates EAT inflammation by reducing GAPDH malonylation via downregulating the expression of ACC1 through increasing ketone bodies, thus attenuating atrial fibrosis.

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关键词

atrial fibrillation, atrial fibrosis, epicardial adipose tissue, inflammation, sodium glucose co-transporter 2 inhibitor

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