Neuroimaging-Derived Predicted Brain Age and Alcohol Use Among Community-Dwelling Older Adults

•What is the primary question addressed by this study?Is light to moderate alcohol use associated with biomarker of slower brain aging among older community dwelling adults?•What is the main finding of this study?Heavier drinkers, those drinking more than 2 drinks per day, showed older than expected predicted brain age; those drinking less did not show younger than expected predicted brain age relative to nondrinkers.•What is the meaning of the finding?Light and moderate alcohol use does not appear to be protective against age-related structural changes in the brain, but heavier alcohol use is associated with evidence of greater neurodegeneration with age.