Cracking the case of m 7 G modification in human tRNAs

Nature structural & molecular biology（2023）

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摘要

The RNA methyltransferase (MTase) METTL1 catalyzes N 7 -methylguanosine (m 7 G) modification at position 46 in human transfer RNAs (tRNAs). Its dysregulation drives tumorigenesis in many cancer types. Two papers now reveal the structural basis of this tRNA maturation event.

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关键词

Molecular biology,Translation,tRNAs,Life Sciences,general,Biochemistry,Protein Structure,Membrane Biology,Biological Microscopy

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