Fabrication of hesperidin hybrid lecithin-folic acid silver nanoparticles and its evaluation as anti-arthritis formulation in autoimmune arthritic rat model

Tooba Jabri,Talat Roome,Anam Razzak,Sabahat Aziz,Muhammad Imran,Bushra Sikandar,Abdelbary Elhissi,Shafiullah,Shazmeen Mohammad Aslam,Muhammad RazaShah

Journal of Molecular Structure（2023）

引用 3|浏览12

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摘要

•Hesperidin, a flavone inhibits the chronic and acute inflammation•L-HP-FA-AgNPs were synthesized for the targeted delivery of HP in arthritic model.•Anti-arthritic and anti-inflammatory effect was evaluated through molecular analysis•It provides a novel therapeutic strategy to overcome the irreversible damage in RA

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关键词

Hesperidin,silver Nanoparticles,Cytokines,TLRs Expression,Arthritis,Receptor activator of nuclear factor kappa B ligand (RANKL)

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