Clinical outcomes and characteristics of patients with TP53 -mutated myelodysplastic syndromes.

Lijuan Zhang,Kankan Chen,Yingying Li,Qiuni Chen,Wenting Shi,Tingting Ji,Hong Tao,Zhengmei He,Chunling Wang,Liang Yu

Hematology (Amsterdam, Netherlands)（2023）

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摘要

-mutated primary MDS patients were associated with higher frequency of cytogenetic abnormalities, with 5q- karyotype, CK, AML transformation, higher risk IPSS-R, lower MCV and sensitive to HMA treatment, but worse survival.

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关键词

Primary myelodysplastic syndromes,TP53 mutation,mean corpuscular volume,prognosis

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