Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure.

Jonas Skogestad,Ingrid Albert,Karina Hougen,Gustav B Lothe,Marianne Lunde, Olav Søvik Eken, Ioanni Veras, Ngoc Trang Thi Huynh, Mira Børstad,Serena Marshall,Xin Shen,William E Louch,Emma Louise Robinson,Joseph C Cleveland,Amrut V Ambardekar,Jessica A Schwisow,Eric Jonas, Ana I Calejo,Jens Preben Morth,Kjetil Taskén,Arne Olav Melleby,Per Kristian Lunde,Ivar Sjaastad,Cathrine Rein Carlson,Jan Magnus Aronsen

Circulation（2023）

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摘要

Our results suggest that PDE3A regulates SERCA2 activity through direct binding, independently of the catalytic activity of PDE3A. Targeting the SERCA2/PDE3A interaction prevented cardiac mortality after AB, most likely by improving cardiac contractility.

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关键词

calcium,excitation contraction coupling,heart failure,phosphodiesterase 3A,sarco-endoplasmic reticulum Ca2+- ATPase

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