Severe influenza infection is associated with inflammatory programmed cell death in infected macrophages.

André C Ferreira,Carolina Q Sacramento,Filipe S Pereira-Dutra,Natália Fintelman-Rodrigues,Priscila P Silva,Mayara Mattos,Caroline S de Freitas,Andressa Marttorelli,Gabrielle R de Melo,Mariana M Campos,Isaclaudia G Azevedo-Quintanilha,Aluana S Carlos,João Vítor Emídio,Cristiana C Garcia,Patrícia T Bozza,Fernando A Bozza,Thiago M L Souza

Frontiers in cellular and infection microbiology（2023）

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摘要

In summary, we demonstrated a positive feedback loop of events that led to necroptosis and exacerbated inflammation in IAV-infected macrophages. Our results highlight an additional mechanism involved in severe influenza that could be attenuated with clinically available therapies.

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TNF,etanercept,influenza virus,macrophages,necroptosis

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