Examining the causal mediating role of cardiovascular disease on the effect of subclinical cardiovascular disease on cognitive impairment via separable effects.

Ryan M Andrews,Ilya Shpitser,Vanessa Didelez,Paulo H M Chaves,Oscar L Lopez,Michelle C Carlson

The journals of gerontology. Series A, Biological sciences and medical sciences（2023）

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摘要

We found that the effect of sCVD on cognitive impairment does not seem to be mediated by CVD, both overall and within APOE-4 subgroups. Our results were critically assessed via sensitivity analyses, and they were found to be robust. Future work is needed to fully understand the relationship between sCVD, CVD, and cognitive impairment.

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关键词

Cognitive Impairment,Mediation analysis,Neuroepidemiology,Subclinical cardiovascular disease

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