Cancer-specific tissue-resident memory T-cells express ZNF683 in colorectal cancer.

Masatoshi Kitakaze,Mamoru Uemura,Tomoaki Hara,Ryota Chijimatsu,Daisuke Motooka,Toshiro Hirai,Masamitsu Konno,Daisuke Okuzaki,Yuki Sekido,Tsuyoshi Hata,Takayuki Ogino,Hidekazu Takahashi,Norikatsu Miyoshi,Ken Ofusa,Tsunekazu Mizushima,Hidetoshi Eguchi,Yuichiro Doki,Hideshi Ishii

British journal of cancer（2023）

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摘要

The number of CD103/CD8 TILs is a prognostic predictive factor in CRC. In addition, we identified the ZNF683 expression as one of the candidate markers of cancer-specific Trm cells. IFN-γ and TCR signalling and ZNF683 expression are involved in Trm cell activation in tumours and are promising targets for cancer immunity regulation.

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关键词

colorectal cancer-specific,znf683,tissue-resident,t-cells

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