Validation of a Polygenic Score for Beta-Blocker Survival Benefit in Patients With Heart Failure Using the United Kingdom Biobank.

HomeCirculation: Genomic and Precision MedicineVol. 16, No. 2Validation of a Polygenic Score for Beta-Blocker Survival Benefit in Patients With Heart Failure Using the United Kingdom Biobank No AccessLetterRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessLetterRequest AccessFull TextValidation of a Polygenic Score for Beta-Blocker Survival Benefit in Patients With Heart Failure Using the United Kingdom Biobank David E. Lanfear, Jasmine A. Luzum, Ruicong She, Jia Li, Hani N. Sabbah, Nicole Zeld, Bin Liu, Edward Peterson and L. Keoki Williams David E. LanfearDavid E. Lanfear Correspondence to: David E. Lanfear, MD, MS, Henry Ford Health System, 2799 W Grand Blvd, K14 Detroit, MI 48202. Email E-mail Address: [email protected] https://orcid.org/0000-0001-6471-1483 Center for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Hospital, Detroit, MI (D.E.L., J.A.L., N.Z., L.K.W.). Heart and Vascular Institute (D.E.L., H.N.S.), Henry Ford Health System, Detroit, MI. Search for more papers by this author , Jasmine A. LuzumJasmine A. Luzum https://orcid.org/0000-0003-3639-717X Center for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Hospital, Detroit, MI (D.E.L., J.A.L., N.Z., L.K.W.). Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI (J.A.L.). Search for more papers by this author , Ruicong SheRuicong She Department of Public Health Sciences (R.S., J.L., B.L., E.P.), Henry Ford Health System, Detroit, MI. Search for more papers by this author , Jia LiJia Li https://orcid.org/0000-0002-5931-3058 Department of Public Health Sciences (R.S., J.L., B.L., E.P.), Henry Ford Health System, Detroit, MI. Search for more papers by this author , Hani N. SabbahHani N. Sabbah https://orcid.org/0000-0002-2850-6105 Heart and Vascular Institute (D.E.L., H.N.S.), Henry Ford Health System, Detroit, MI. Search for more papers by this author , Nicole ZeldNicole Zeld https://orcid.org/0000-0001-9096-8071 Center for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Hospital, Detroit, MI (D.E.L., J.A.L., N.Z., L.K.W.). Search for more papers by this author , Bin LiuBin Liu https://orcid.org/0000-0002-3280-9336 Department of Public Health Sciences (R.S., J.L., B.L., E.P.), Henry Ford Health System, Detroit, MI. Search for more papers by this author , Edward PetersonEdward Peterson Department of Public Health Sciences (R.S., J.L., B.L., E.P.), Henry Ford Health System, Detroit, MI. Search for more papers by this author and L. Keoki WilliamsL. Keoki Williams https://orcid.org/0000-0002-7592-5791 Center for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Hospital, Detroit, MI (D.E.L., J.A.L., N.Z., L.K.W.). Search for more papers by this author Originally published3 Mar 2023https://doi.org/10.1161/CIRCGEN.121.003835Circulation: Genomic and Precision Medicine. 2023;16FootnotesFor Sources of Funding and Disclosures, see page XXX.Correspondence to: David E. Lanfear, MD, MS, Henry Ford Health System, 2799 W Grand Blvd, K14 Detroit, MI 48202. Email [email protected]orgReferences1. Writing C, Maddox TM, Januzzi JL, Allen LA, Breathett K, Butler J, Davis LL, Fonarow GC, Ibrahim NE, Lindenfeld J, et al. 2021 update to the 2017 acc expert consensus decision pathway for optimization of heart failure treatment: answers to 10 pivotal issues about heart failure with reduced ejection fraction: a report of the american college of cardiology solution set oversight committee.J Am Coll Cardiol. 2021; 77:772–810. doi: 10.1016/j.jacc.2020.11.022CrossrefMedlineGoogle Scholar2. Talameh JA, Lanfear DE. Pharmacogenetics in chronic heart failure: new developments and current challenges.Curr Heart Fail Rep. 2012; 9:23–32. doi: 10.1007/s11897-011-0076-2CrossrefMedlineGoogle Scholar3. Lanfear DE, Luzum JA, She R, Gui H, Donahue MP, O’Connor CM, Adams KF, Sanders-van Wijk S, Zeld N, Maeder MT, et al. Polygenic score for beta-blocker survival benefit in european ancestry patients with reduced ejection fraction heart failure.Circ Heart Fail. 2020; 13:e007012. doi: 10.1161/CIRCHEARTFAILURE.119.007012LinkGoogle Scholar4. Lanfear DE, Hrobowski T, Peterson EL, Wells K, Swadia T, Spertus JA, Williams LK. Association of beta blocker exposure with outcomes in heart failure differs between african american and white patients.Circ Heart Fail. 2012; 5:202. doi: 10.1161/CIRCHEARTFAILURE.111.965780LinkGoogle Scholar5. Pocock SJ, Ariti CA, McMurray JJ, Maggioni A, Kober L, Squire IB, Swedberg K, Dobson J, Poppe KK, Whalley GA, et al; Meta-Analysis Global Group in Chronic Heart Failure. Predicting survival in heart failure: a risk score based on 39 372 patients from 30 studies.Eur Heart J. 2013; 34:1404–1413. doi: 10.1093/eurheartj/ehs337CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetails April 2023Vol 16, Issue 2 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCGEN.121.003835PMID: 36866666 Originally publishedMarch 3, 2023 Keywordsadrenergic beta antagonistssurvivalprecision medicinegenome wide association studyheart failurePDF download Advertisement SubjectsHeart FailurePrecision Medicine