Distinct dynamics of antigen-specific induction and differentiation of different CD11c+Tbet+ B-cell subsets

Juulke Steuten,Amélie V. Bos,Lisan H. Kuijper,Mathieu Claireaux,Wouter Olijhoek,George Elias,Mariel C. Duurland,Tineke Jorritsma,Casper Marsman,Alberta G.A. Paul,Juan J. Garcia Vallejo,Marit J. van Gils,Luuk Wieske,Taco W. Kuijpers,Filip Eftimov,S. Marieke van Ham,Anja ten Brinke

The Journal of allergy and clinical immunology（2023）

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摘要

Overall, CD11cTbet B cells encompass heterogeneous subpopulations, of which primarily ABCs as well as DN2 B cells respond early to immune challenge and display a pre-antibody-secreting cell phenotype.

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关键词

CD11c+Tbet+ atypical B cell,age-associated B cell,double negative 2,activated naive,antibody-secreting cell differentiation,SARS-CoV-2 vaccination

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