Discovery of Transacting Long Noncoding RNAs That Regulate Smooth Muscle Cell Phenotype.

Huitong Shi,Trieu Nguyen,Quanyi Zhao,Paul Cheng,Disha Sharma,Hyun-Jung Kim,Juyong Brian Kim,Robert Wirka,Chad S Weldy,João P Monteiro,Thomas Quertermous

Circulation research（2023）

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摘要

Expression of a large and diverse set of lncRNAs in human coronary artery SMC are highly dynamic in response to CAD-related stimuli. The dynamic changes in expression of these lncRNAs correspond to alterations in transcriptional programs that are relevant to CAD, suggesting a critical role for lncRNAs in SMC phenotypic transition and human atherosclerotic disease.

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关键词

coronary artery disease,long-noncoding RNA,phenotypic transition,smooth muscle cell

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