The risk of radiation-induced neurocognitive impairment and the impact of sparing the hippocampus during pediatric proton cranial irradiation.

Daniel Gram,N Patrik Brodin,Thomas Björk-Eriksson,Karsten Nysom,Per Munck Af Rosenschöld

Acta oncologica (Stockholm, Sweden)（2023）

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摘要

We present estimates of potential clinical benefit in terms of neurocognitive impairment and demonstrate the possibility of considerably reducing neurocognitive adverse effects, minimally compromising target coverage locally using HS-IMPT.

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关键词

Neurocognitive impairment,craniospinal irradiation,hippocampal avoidance,normal tissue complication probability,pediatric hippocampus,tumor control probability

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