Duodenal alpha-Synuclein Pathology and Enteric Gliosis in Advanced Parkinson's Disease.

Aron Emmi,Michele Sandre,Francesco Paolo Russo,Giulia Tombesi,Federica Garrì,Marta Campagnolo,Miryam Carecchio,Roberta Biundo,Gaya Spolverato,Veronica Macchi,Edoardo Savarino,Fabio Farinati,Piero Parchi,Andrea Porzionato,Luigi Bubacco,Raffaele De Caro,Gabor G Kovacs,Angelo Antonini

Movement disorders : official journal of the Movement Disorder Society（2023）

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摘要

We found evidence of synuclein pathology and gliosis in the duodenum of patients with PD, including early de novo cases. Future studies are required to evaluate how early in the disease process duodenal pathology occurs and its possible contribution to levodopa effect in chronic patients. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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关键词

Parkinson's disease,alpha-synuclein,enteric nervous system,gastrointestinal biopsies,neuropathology

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