GA-OH enhances the cytotoxicity of photon and proton radiation in HPV + HNSCC cells.

Lennox Chitsike,Antonella Bertucci,Marcelo Vazquez, Steve Lee,Juli J Unternaehrer,Penelope J Duerksen-Hughes

Frontiers in oncology（2023）

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摘要

The enhanced combinatorial cytotoxicity found in this study indicates the strong potential of E6 inhibition as a strategy to sensitize cells to radiation. Future research is warranted to further characterize the interaction of GA-OH derivatives and other E6-specific inhibitors with radiation, as well as its potential to improve the safety and effectiveness of radiation treatment for patients with oropharyngeal cancer.

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关键词

E6,HPV+OPSCC,HPV- OPSCC,de-escalation,photons,protons,radio-sensitization,radiotherapy

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