The Nerve Growth Factor Receptor (NGFR/p75 NTR ): A Major Player in Alzheimer's Disease.

International journal of molecular sciences(2023)

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摘要
Alzheimer's disease (AD) represents the most prevalent type of dementia in elderly people, primarily characterized by brain accumulation of beta-amyloid (Aβ) peptides, derived from Amyloid Precursor Protein (APP), in the extracellular space () and intracellular deposits of the hyperphosphorylated form of the protein tau (p-tau; ). The Nerve growth factor receptor (NGFR/p75) represents a low-affinity receptor for all known mammalians neurotrophins (i.e., proNGF, NGF, BDNF, NT-3 e NT-4/5) and it is involved in pathways that determine both survival and death of neurons. Interestingly, also Aβ peptides can blind to NGFR/p75 making it the "ideal" candidate in mediating Aβ-induced neuropathology. In addition to pathogenesis and neuropathology, several data indicated that NGFR/p75 could play a key role in AD also from a genetic perspective. Other studies suggested that NGFR/p75 could represent a good diagnostic tool, as well as a promising therapeutic target for AD. Here, we comprehensively summarize and review the current experimental evidence on this topic.
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关键词
Alzheimer’s disease,NGFR,amyloid-beta,diagnosis,expression,nerve growth factor receptor,neuropathology,p75NTR,signaling pathways,treatment
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