The Nerve Growth Factor Receptor (NGFR/p75 NTR ): A Major Player in Alzheimer's Disease.
International journal of molecular sciences(2023)
摘要
Alzheimer's disease (AD) represents the most prevalent type of dementia in elderly people, primarily characterized by brain accumulation of beta-amyloid (Aβ) peptides, derived from Amyloid Precursor Protein (APP), in the extracellular space () and intracellular deposits of the hyperphosphorylated form of the protein tau (p-tau; ). The Nerve growth factor receptor (NGFR/p75) represents a low-affinity receptor for all known mammalians neurotrophins (i.e., proNGF, NGF, BDNF, NT-3 e NT-4/5) and it is involved in pathways that determine both survival and death of neurons. Interestingly, also Aβ peptides can blind to NGFR/p75 making it the "ideal" candidate in mediating Aβ-induced neuropathology. In addition to pathogenesis and neuropathology, several data indicated that NGFR/p75 could play a key role in AD also from a genetic perspective. Other studies suggested that NGFR/p75 could represent a good diagnostic tool, as well as a promising therapeutic target for AD. Here, we comprehensively summarize and review the current experimental evidence on this topic.
更多查看译文
关键词
Alzheimer’s disease,NGFR,amyloid-beta,diagnosis,expression,nerve growth factor receptor,neuropathology,p75NTR,signaling pathways,treatment
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要