Effect of a combination of pemafibrate and a mild low-carbohydrate diet on obese and non-obese patients with metabolic-associated fatty liver disease.

Yuichiro Suzuki,Shinya Maekawa, Kohji Yamashita,Leona Osawa,Yasuyuki Komiyama,Natsuko Nakakuki,Hitomi Takada,Masaru Muraoka,Mitsuaki Sato,Shinichi Takano,Mitsuharu Fukasawa,Tatsuya Yamaguchi,Satoshi Funayama,Hiroyuki Morisaka,Hiroshi Onishi,Nobuyuki Enomoto

Journal of gastroenterology and hepatology（2023）

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摘要

Combined treatment with pemafibrate and a low-carbohydrate diet resulted in weight loss and improvements in ALT, MRE, and MRI-PDFF in MAFLD patients. Although such improvements were associated with weight loss in obese patients, the improvements were observed irrespective of weight loss in non-obese patients, indicating this combination can be effective both in obese and non-obese MAFLD patients.

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关键词

MAFLD,MRE,MRI-PDFF,low-carbohydrate diet (LCD),pemafibrate

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