A novel biologically active xylaphenoside from the endophytic fungus Xylaria CGMCC No.5410

A novel 3,4-dihydroisocoumarin glycoside ( 1 ) was obtained from the culture of endophytic fungal Xylaria CGMCC No.5410 from the leaves of Selaginella moellendorffii Hieron, together with five known compounds ( 2–6 ). Their structures elucidations were conducted by HRESIMS, NMR and IR spectroscopic analysis. All the isolated compounds were evaluated for their antimicrobial, anti-tumor, and anti-HIV-1 activities. Compound 1 only displayed weak antimicrobial activity against micrococcus luteus . The other known compounds showed different antimicrobial, anti-tumor, or anti-HIV-1 activities.