Inhibition of DDX3X alleviates persistent inflammation, immune suppression and catabolism syndrome in a septic mice model

Yukun Liu,Yongsheng Zhang,Chuntao Wang,Qinxin Liu,Tianyu Li,Wei Wang,Fan Yang,Zhanfei Li,Xiangjun Bai,Yuchang Wang

International Immunopharmacology（2023）

引用 2|浏览33

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摘要

•Inhibition of DDX3X protects septic mice and attenuates immune response.•RK-33 reduces skeletal muscle wasting and oxidative stress.•RK-33 prevents the progression of sepsis to Persistent Inflammation, Immune Suppression, and Catabolism Syndrome and improves the prognosis of sepsis mice.

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关键词

Skeletal muscle atrophy,NLRP3,T cells,Sepsis,PICS,DDX3X

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