HIF1α and HIF2α regulate non-small-cell lung cancer dedifferentiation via expression of Sox2 and Oct4 under hypoxic conditions

Shuanglong Xiong,Donglin Wang,Yin Tang,Songmei Lu,Lumi Huang,Zhijuan Wu,Shuangyi Lei,Guanzhong Liang,Dan Yang,Dairong Li,Yan Li

Gene（2023）

引用 2|浏览7

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摘要

•HIF1α/HIF2α-Sox2/Oct4 network regulates Lung cancer cells dedifferentiation in hypoxia.•Both HIF1α and HIF2α upregulates Sox2 and Oct4 in hypoxia.•Both Sox2 and Oct4 upregulates CD133 and CD44 in hypoxia.•Improving hypoxic microenvironment may be a good way for cancer treatment.•Targeting HIF1α, HIF2α, Sox2 and Oct4 may be a good way for cancer treatment.

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关键词

Lung cancer stem cells,Hypoxia,Dedifferentiation,HIF1α and HIF2α,Sox2 and Oct4

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