Systematic Review and Meta-Analysis of the Influence of Genetic Variation on Ototoxicity in Platinum-Based Chemotherapy.

Daniel Z Hong,Thaned C C Ong, Dhayan P Timbadia, Hui T A Tan,Eunice D Kwa,Wan Q Chong,Boon C Goh,Woei S Loh,Kwok S Loh,Ene C Tan,Joshua K Tay

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery（2023）

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摘要

Our meta-analysis presents polymorphisms that exert ototoxic or otoprotective effects in patients undergoing PBC. Importantly, several of these alleles are observed at high frequencies globally, highlighting the potential for polygenic screening and cumulative risk evaluation for personalized care.

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genetics,ototoxicity,platinum chemotherapy,single-nucleotide polymorphism

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