Acute IL-6 exposure triggers canonical IL6Ra signaling in hiPSC microglia, but not neural progenitor cells.

Amalie C M Couch,Shiden Solomon,Rodrigo R R Duarte,Alessia Marrocu,Yiqing Sun,Laura Sichlinger,Rugile Matuleviciute,Lucia Dutan Polit,Bjørn Hanger,Amelia Brown,Shahram Kordasti,Deepak P Srivastava,Anthony C Vernon

Brain, behavior, and immunity（2023）

引用 3|浏览13

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摘要

Our data provide evidence for cell specific effects of acute IL-6 exposure in a human model system, ultimately suggesting that microglia-NPC co-culture models are required to study how IL-6 influences human cortical neural progenitor cell development in vitro.

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关键词

Human induced-pluripotent stem cells,IL-6,Microglia,Neural progenitor cells,Neurodevelopmental disorders

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