Health equity considerations in pragmatic trials in Alzheimer's and dementia disease: Results from a methodological review.

Stuart G Nicholls,Ahmed A Al-Jaishi, Harrison Niznick,Kelly Carroll,Mohamad Tarek Madani,Katherine D Peak,Leen Madani,Pascale Nevins,Lionel Adisso,Fan Li,Charles Weijer,Susan L Mitchell,Vivian Welch,Ana R Quiñones,Monica Taljaard

Alzheimer's & dementia (Amsterdam, Netherlands)（2023）

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摘要

Few pragmatic trials are explicitly designed to inform equity-relevant objectives.Few pragmatic trials take steps to increase enrollment from equity-relevant groups.Disaggregated results across equity-relevant groups are seldom reported.Adherence to existing tools (e.g., IMPACT Best Practices, CONSORT-Equity) is key.

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关键词

Alzheimer's disease,cluster randomized trials,covariate adjustment,dementia,health equity,pragmatic trials,randomization,subgroup analyses,treatment effect heterogeneity

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