Genetic findings in a patient with paradoxical pyoderma gangrenosum induced by brodalumab.

Italo Francesco Aromolo,Carlo Alberto Maronese,Chiara Moltrasio,Francesca Boggio,Silvia Alberti Violetti,Gianluca Avallone,Nicole Morini,Carlo Giovanni Carrera,Giovanni Genovese,Angelo Valerio Marzano

Clinical and experimental dermatology（2023）

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摘要

We describe a patient with psoriasis who developed pyoderma gangrenosum while on treatment with brodalumab, an anti-interleukin (IL)-17 receptor monoclonal antibody. Genetic analyses revealed heterozygous polymorphisms within the promoter region of the IL-6 (promoter polymorphism -174 G/C) and IL-10 genes (promoter polymorphism -1082 A/G).

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