The heparan sulfate mimetic Muparfostat aggravates steatohepatitis in obese mice due to its binding affinity to lipoprotein lipase.
British journal of pharmacology(2023)
摘要
The binding activity of HS mimetics to lipoprotein lipase should be investigated as an additional pharmacological effect during heparanase inhibitor drug discovery. This study also provides novel evidence for an increased risk of drug-induced liver injury in obese individuals.
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关键词
heparan sulfate mimetic,heparanase inhibitor,hepatic steatosis,lipoprotein lipase,obesity
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