Functional characterization of a novel aminoglycoside phosphotransferase, APH(9)-Ic, and its variant from Stenotrophomonas maltophilia .

Weina Shi,Junwan Lu,Chunlin Feng,Mengdi Gao,Anqi Li,Shuang Liu,Lei Zhang,Xueya Zhang,Qiaoling Li,Hailong Lin,Xi Lin,Kewei Li,Hailin Zhang,Yunliang Hu,Guangli Wang,Qiyu Bao,Weiyan Jiang

Frontiers in cellular and infection microbiology（2022）

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摘要

We characterized a novel AG resistance gene aph(9)-Ic and its variant aph(9)-Ic1 that mediated spectinomycin resistance from S. maltophilia. The identification of the novel AG resistance genes will assist us in elucidating the complexity of resistance mechanisms in microbial populations.

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关键词

APH(9)-Ic,Stenotrophomonas maltophilia,aminoglycoside 9-phosphotransferase,aminoglycoside resistance,aminoglycoside-modifying enzyme

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