A molecular dynamics simulation study to understand the effect of cholesterol and tissue factor palmitoylation on tissue factor-factor VIIa-factor Xa ternary complex in different lipid environments.
Journal of thrombosis and haemostasis : JTH（2023）
摘要
Analysis of molecular dynamic simulation data suggests that the presence of cholesterol and palmitoylation may contribute to structural rigidity, stability, and compactness of key domains of TF-FVIIa-FXa by augmenting protein-protein and protein-lipid interactions.
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关键词
cholesterol,factor VIIa,factor Xa,molecular dynamics simulation,palmitoylation,protein–lipid interaction,protein–protein interaction,tissue factor
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