ADAR1 Non-Editing Function in Macrophage Activation and Abdominal Aortic Aneurysm.

Dunpeng Cai,Chenming Sun,Takashi Murashita,Xingyi Que,Shi-You Chen

Circulation research（2023）

引用 4|浏览15

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摘要

Macrophage ADAR1 promotes aneurysm formation in both mouse and human arteries through a novel mechanism, that is, Drosha protein degradation, which inhibits the processing of microRNAs targeting NF-kB signaling and thus elicits macrophage-mediated vascular inflammation in AAA.

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关键词

abdominal aortic aneurysm,adenosine deaminases acting on RNA1,humanized AAA model,macrophage,microRNA

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