Exploring the Overlap Between Alopecia Areata and Major Depressive Disorder: Epidemiological and Genetic Perspectives

J. C. Foo,S. Redler,A. J. Forstner,F. B. Basmanav, L. Pethukova,J. Guo,F. Streit,S. H. Witt,L. Sirignano,L. Zillich,S. Avasthi,S. Ripke,A. M. Christiano,F. Tesch,J. Schmitt,M. M. Nöthen,R. C. Betz,M. Rietschel,J. Frank

Journal of the European Academy of Dermatology and Venereology（2023）

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摘要

As in previous research, AA patients showed an increased prevalence of MDD. The present analyses suggest that genetic overlap may be confined to the MHC region, which is implicated in immune function. More detailed investigation is required to refine understanding of how the MHC is involved in the development of AA and MDD comorbidity.

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