Tumor-Educated Platelet Extracellular Vesicles: Proteomic Profiling and Crosstalk with Colorectal Cancer Cells.

Annalisa Contursi,Rosa Fullone, Paulina Szklanna-Koszalinska,Simone Marcone,Paola Lanuti,Francesco Taus,Alessandra Meneguzzi,Giulia Turri,Melania Dovizio,Annalisa Bruno,Corrado Pedrazzani,Stefania Tacconelli,Marco Marchisio,Patrizia Ballerini,Pietro Minuz,Patricia Maguire,Paola Patrignani

Cancers（2023）

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摘要

We show that mEVs released from thrombin-activated platelets of CRC patients have distinct features (size distribution and proteomics cargo) vs. HS and promote prometastatic and prothrombotic phenotypes in cancer cells. The analysis of platelet-derived mEVs from CRC patients could provide valuable information for developing an appropriate treatment plan.

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关键词

colorectal cancer,cyclooxygenase-2,epithelial-mesenchymal transition,platelet-derived extracellular vesicles,thromboxane A2

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