Neuroprotective Mechanisms of Amylin Receptor Activation, Not Antagonism, in the APP/PS1 Mouse Model of Alzheimer's Disease.

Rachel R Corrigan,Luis Labrador,John Grizzanti,Megan Mey,Helen Piontkivska,Gemma Casadesús

Journal of Alzheimer's disease : JAD（2023）

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摘要

These data suggest an uncoupling of functional and pathology-related events and highlighting a more complex receptor system and pharmacological relationship that must be carefully studied to clarify the role of amylin in CNS function and AD.

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关键词

Alzheimer’s disease,RNA sequencing,amylin,amyloid-β,metabolism,receptor antagonism

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