Knee immobilization reproduces key arthrofibrotic phenotypes in mice.

Louis Dagneaux,Afton K Limberg,Aaron R Owen,Jacob W Bettencourt,Amel Dudakovic,Banu Bayram,Naomi M Gades,Joaquin Sanchez-Sotelo,Daniel J Berry,Andre van Wijnen,Mark E Morrey,Matthew P Abdel

Bone & joint research（2023）

引用 0|浏览10

暂无评分

摘要

This study established a novel mouse model of robust knee contracture without evidence of OA. This was appreciated consistently after eight weeks of immobilization and was irrespective of length of remobilization. As such, this arthrofibrotic model provides opportunities to investigate molecular pathways and therapeutic strategies.Cite this article: 2023;12(1):58-71.

查看译文

关键词

Animal models,Contracture,Fibrosis,Genetic predisposition,Knees,Murine,articular injury,cartilage degeneration,contractures,extension angles,histological analysis,immobilization,mouse models,sutures

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要