Recent advances of surface acoustic wave-based sensors for noninvasive cell analysis.

In the past years, the application of surface acoustic waves (SAWs) as sensors for biological applications has reached high relevance in the field of biotechnology. From rapid advances in designs and materials, new opportunities have emerged, especially for sensing of living cells. Additionally, the combination of SAW sensors with microfluidics and optical microscopy has expanded the market of possible applications. Differentiation of infected and healthy red blood cells or aggressive and nonaggressive tumor cells, and monitoring of wound healing, bacteria, or viral antigen concentrations via SAW-based sensors are only a few examples of recent achievements in cell biology. The rapid growth of this field requires frequent reviewing of the recent progress to maintain high research standards and promote future developments.