Evaluation and limitations of different approaches among COVID-19 fatal cases using whole-exome sequencing data.

Natalia Forgacova,Zuzana Holesova,Rastislav Hekel,Tatiana Sedlackova,Zuzana Pos,Lucia Krivosikova,Pavol Janega,Kristina Mikus Kuracinova,Pavel Babal,Peter Radvak,Jan Radvanszky,Juraj Gazdarica,Jaroslav Budis,Tomas Szemes

BMC genomics（2023）

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摘要

Although our results proved the likely involvement of host genetic factors pointed out by previous studies looking into severity of COVID-19 disease, careful considerations of the molecular-testing strategies and the evaluated genomic positions may have a strong impact on the utility of genomic testing.

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关键词

COVID-19,Genetic association,Gnomad,Non-invasive prenatal testing,Polymorphisms,SARS-CoV-2,Whole-exome sequencing

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