Dissection of Functional Domains of Orc1-2, the Archaeal Global DNA Damage-Responsive Regulator.

Xiaotong Liu,Mengmeng Sun,Ruyi Xu,Yulong Shen,Qihong Huang,Xu Feng,Qunxin She

International Journal of Molecular Sciences（2022）

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摘要

Orc1-2 is a non-initiator ortholog of archaeal/eukaryotic Orc1 proteins, which functions as a global regulator in DNA damage-responsive (DDR) expression. As for Orc1 initiators, the DDR regulator harbors an AAA+ ATPase domain, an Initiator-Specific Motif (ISM) and a winged-helix (wH) DNA-binding domain, which are also organized in a similar fashion. To investigate how Orc1-2 mediates the DDR regulation, the orc1-2Saccharolobus islandicusorc1-2

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关键词

origin recognition complex,DNA damage response,AAA+ ATPase,winged-helix domain,archaea,global regulator

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