RNA modifications detection by comparative Nanopore direct RNA sequencing

Adrien Leger,Paulo P. Amaral,Luca Pandolfini,Charlotte Capitanchik,Federica Capraro,Valentina Miano,Valentina Migliori,Patrick Toolan-Kerr,Theodora Sideri,Anton J. Enright,Konstantinos Tzelepis,Folkert J. van Werven,Nicholas M. Luscombe,Isaia Barbieri,Jernej Ule,Tomas Fitzgerald,Ewan Birney,Tommaso Leonardi,Tony Kouzarides

Nature Communications（2021）

引用 122|浏览27

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摘要

Nanopore direct RNA Sequencing data contain information about the presence of RNA modifications, but their detection poses substantial challenges. Here the authors introduce Nanocompore, a new methodology for modification detection from Nanopore data.

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