Plasma transfusion-transmission of Zika virus in mice and macaques.

Koen K A Van Rompay,Lark L Coffey,JoAnn L Yee,Anil Singapuri,Jackson Stuart,Marion C Lanteri, Felicia Santa Maria,Kai Lu,Inderdeep Singh,Sonia Bakkour,Mars Stone,Phillip C Williamson,Marcus O Muench,Michael P Busch,Graham Simmons

Transfusion（2023）

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摘要

Significant risks of ZIKV TT are likely confined to a relatively short viremic window before seroconversion, and that sensitive nucleic acid amplification testing likely identifies the majority of infectious plasma. PRT was demonstrated to be effective at preventing ZIKV TT. Considering that there is no approved ZIKV vaccine, these data are relevant to mitigate the risk of TT during the future ZIKV outbreaks.

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关键词

Infectious disease testing,pathogen reduction,transfusion-transmitted disease

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