A Phase II Single-arm Study of Palbociclib in Patients With HER2-positive Breast Cancer With Brain Metastases and Analysis of ctDNA in Patients With Active Brain Metastases.

Ami N Shah,Cesar A Santa-Maria,Dhruvika Mukhija,Nikita Shah,Anthony K Kang,Priya Kumthekar,Kirsten Burdett,Shruti Chandra, Jenny Chang,Dean Tsarwhas, Jill Woodman,Borko Jovanovic,Lorenzo Gerratana,William Gradishar,Massimo Cristofanilli

Clinical breast cancer（2023）

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摘要

Palbociclib did not demonstrate activity in HER2+ MBC with BM. Patients with progressive BM but stable, responding, or absent systemic disease have low VAF and number of alterations detected by ctDNA analysis from blood.

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关键词

CDK4/6i,CNS metastases,Liquid biopsy,Metastatic breast cancer

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