Nanoconfinement effect on the hydrolysis of cisplatin

•The hydrolysis of cisplatin is less favorable inside the CNH cavity by 7 kcal mol−1.•The energy barrier for hydrolysis of cisplatin is reduced by 9 kcal mol−1 in the CNH.•Structural and energetic effects in the CNH cause a reduction of the energy barrier.•The confined process of hydrolysis is 4-orders of magnitude faster than this one for free cisplatin.